Luteolin and triptolide: Potential therapeutic compounds for post-stroke depression via protein STAT

Post stroke depression (PSD) is a common neuropsychiatric complication following closely associated with the immune system. The development of medications for PSD remains to be considerable challenge due unclear mechanism PSD. Multiple researches agree that functions gene ontology (GO) are efficient investigation disease mechanisms, and DeepPurpose (DP) extremely valuable mining new drugs. However, GO terms DP have not yet been applied explore pathogenesis drug treatment This study aimed interpret discover important candidates targeting risk proteins, based on immune-related informatics algorithms. According genes PSD, we identified 335 37 compounds. Based construction function network, found STAT protein may pivot in underlying Additionally, also established networks Protein-Protein Interaction as well Gene-GO facilitate evaluation key genes. DP, total candidate compounds 7 proteins were potential therapy Furthermore, noted mechanisms by which luteolin triptolide acting STAT-related might involve three crucial pathways, including specifically hsa04010 (MAPK signaling pathway), hsa04151 (PI3K-Akt pathway) hsa04060 (Cytokine-cytokine receptor interaction). Thus, this provided fresh powerful information therapeutic strategies